• "Atsekardol": instructions for use, analogues

    Composition and release form

    The drug "Atsekardol" is made in the form of tablets, which are coated with an enteric coating. Each of them contains 300 mg of the active substance - acetylsalicylic acid, as well as low molecular weight povidone, corn starch, magnesium stearate and a number of other auxiliary components.

    In the package "Atsekardola" - 10 tablets, which are placed in the contour of the cell and a pack of cardboard.

    You can buy medicine without a prescription, but taking it without consulting a doctor is not allowed.

    pharmachologic effect

    The therapeutic effect of this drug is due to the mechanism of the antiplatelet action of acetylsalicylic acid (ASA), which is based on the irreversible inhibition of cyclooxygenase (COX-1). By blocking the synthesis of thromboxane A2 and suppressing platelet aggregation, the drug begins to have a pronounced antiplatelet effect, even when taking small doses.The effect may persist throughout the week (after a single dose).

    In addition, ASA has other mechanisms for the suppression of platelet aggregation.

    Anti-inflammatory, antipyretic and analgesic effects of "Atsekardola" occur when using high dosages of ASA (more than 300 mg per day).


    After taking the drug quickly enough and fully absorbed from the gastrointestinal tract, with the result that ASA begins to turn into the main metabolite - salicylic acid.

    The maximum concentration of the active substance of the drug in the blood plasma reaches 10-20 minutes after administration.

    Due to the acid-resistant shell, which covers the tablets, ASA is not released in the stomach, but in the alkaline environment of the duodenum. As a result, absorption slows down by about 3-6 hours, compared with bezel-like counterparts.

    The metabolism of salicylic acid is limited by the capabilities of the enzyme system. The drug leaves the body through the kidneys. About 80-100% of a single dose of the drug is excreted by the kidneys for a period of up to three days.


    The drug "Atsekardol" is used in order to prevent:

    • acute myocardial infarction (if there are such risk factors as diabetes, high blood pressure, smoking, overweight or old age);
    • recurrent myocardial infarction;
    • ischemic stroke (including patients diagnosed with transient cerebrovascular accident);
    • thromboembolism (after surgery and invasive interventions on the vessels, including coronary artery bypass surgery, angioplasty, coronary artery stenting, etc.);
    • deep vein thrombosis and pulmonary thromboembolism and its branches, including cases associated with prolonged immobilization after extensive surgical interventions).

    In addition, the drug is effective in unstable angina.

    Dosage, duration of treatment and method of application

    Tablets "Atsekardol" you need to drink before meals, drink plenty of liquids. The drug is administered once a day.

    Usually the drug is intended for long courses of therapy. How long they will continue is decided solely by the doctor, depending on the evidence.

    Patients with suspected acute myocardial infarction, the drug is usually prescribed at a dosage of 100 mg per day daily or 300 mg every other day (in this case, the first pill should be chewed in order to accelerate absorption).

    Similarly, the drug is prescribed for the prevention of newly diagnosed acute myocardial infarction (if there are risk factors), as well as to prevent recurrent myocardial infarction and unstable angina.

    Side effect

    When using the drug "Atsekardol" patients may experience various kinds of undesirable effects. Among the most common:

    • on the part of the digestive system: nausea and vomiting, abdominal pain, ulcers and bleeding of the gastrointestinal tract, etc .;
    • on the part of the hematopoietic system: anemia, increased risk of bleeding (due to the inhibitory effect of ASA on platelet aggregation);
    • respiratory system: bronchospasm;
    • on the part of the central nervous system: headaches and dizziness, reduced hearing, tinnitus.

    In addition, in patients receiving "Atsekardol" may in varying degrees of severity occur allergic reactions, in particular:

    • pruritus, rash;
    • hives;
    • angioedema;
    • anaphylactic shock;
    • rhinitis;
    • cardiorespiratory distress syndrome.


    The drug "Atsekardol" is not used in the following cases:

    • erosive and ulcerative lesions of the digestive system organs (in the period of exacerbation);
    • gastrointestinal bleeding;
    • hemorrhagic diathesis;
    • induced by salicylate bronchial asthma;
    • complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to ASA;
    • renal failure in severe (at the level of creatinine clearance (CC) less than 30 ml per minute);
    • severe hepatic impairment (class B and C on the Child-Pugh scale);
    • chronic heart failure (NYHA class III-IV functional class).

    In addition, the drug is not administered simultaneously with methotrexate in a weekly dosage of 15 mg and above.

    A strict contraindication to the use of "Atsekardola" are also:

    • gestation period (I and III trimesters);
    • breastfeeding period;
    • age of patients under 18;
    • lactase deficiency, lactose intolerance, and glucose-galactose malabsorption;
    • hypersensitivity to ASA.

    The drug is prescribed with caution to patients diagnosed with such diseases as:

    • gout, hyperuricemia;
    • gastric ulcer and duodenal ulcer (or history of gastrointestinal bleeding);
    • impaired renal and / or liver function;
    • bronchial asthma;
    • hay fever;
    • nasal polyposis;
    • drug allergy.

    Special control is required with the use of "Atsekardola with concomitant treatment with anticoagulants and in case of upcoming surgical interventions, including tooth extraction and other minor operations.

    During the second trimester of pregnancy, salicylates are used only in view of the rigorous assessment of the likely risks to the fetus and the therapeutic effect for the mother. Patients in this category are advised to prescribe the drug in daily dosages that do not exceed 150 mg. In addition, the treatment should not be long.

    Patients taking "Atsekardol", at the time of therapy, are recommended to refrain from driving and other potentially dangerous activities that require quick reactions and an increased concentration of attention.


    Given the small amount of ASA in the drug "Atsekardol", overdose with this drug is unlikely. Admission to a dosage in excess of the recommended dose is associated with an increased risk of gastrointestinal bleeding, especially in elderly patients.

    The drug in high doses may be accompanied by various manifestations, for example:

    • nausea and vomiting;
    • headache and dizziness;
    • tinnitus, significant hearing loss;
    • increased sweating;
    • confusion;
    • hyperventilation;
    • respiratory alkalosis.


    Among the drugs that are similar in composition and principle of action with "Atsekardolom", in pharmacies are sold, in particular, means:

    • "Anapirin";
    • Aspicor;
    • Cardiomagnyl;
    • Plydol;
    • "Polokard";
    • "Trombogad" and other drugs of domestic and foreign production.

    Some of these drugs can be purchased only with a doctor’s prescription.

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